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Neuroinflammation Thyroid Link

Meaning

The Neuroinflammation Thyroid Link describes the established, reciprocal relationship where chronic, localized inflammation within the central nervous system, termed neuroinflammation, can significantly impair optimal thyroid hormone signaling, and conversely, any form of thyroid dysfunction can exacerbate underlying neuroinflammatory processes. Neuroinflammation has the capacity to directly interfere with the Hypothalamic-Pituitary-Thyroid (HPT) axis and local T4-to-T3 conversion, while a hypothyroid state can compromise the brain’s inherent ability to resolve inflammation and manage oxidative stress. This intricate interaction is a key factor contributing to the cognitive and mood symptoms frequently associated with thyroid disorders.