What is the Origin of Neuroinflammation Resolution?

This concept emerges from neuroimmunology and neuropathology, recognizing that the brain is not immune-privileged in the classical sense but maintains a highly regulated, localized immune response. The term 'Resolution' emphasizes the active, therapeutic goal of returning the brain's immune cells to a quiescent, surveillance state, contrasting with simple anti-inflammatory suppression. This strategy is central to modern cognitive and mental health interventions.

What is the Mechanism of Neuroinflammation Resolution?

Resolution is mediated by modulating the activity of microglia, shifting them from a pro-inflammatory (M1) to a reparative (M2) phenotype, and by promoting the synthesis of specialized pro-resolving mediators (SPMs). Interventions often target gut-brain axis integrity to reduce peripheral inflammatory signals that cross the blood-brain barrier and utilize specific nutraceuticals that inhibit NF-κB signaling. By quieting the inflammatory cascade, the mechanism restores the delicate balance necessary for healthy neurotransmission and neuroplasticity.

Neuroinflammation Resolution

Meaning

The active clinical process of reducing and ultimately resolving chronic, low-grade inflammatory signaling within the central nervous system, which is mediated by activated glial cells like microglia and astrocytes. Unresolved neuroinflammation is a key driver of neuronal dysfunction, cognitive decline, and disruption of the neuroendocrine axes, including the HPA axis. Resolution is a therapeutic goal that aims to restore the brain’s immune privilege and promote a healthy, non-toxic microenvironment for optimal neuronal signaling and plasticity.