What is the Origin of Neuroinflammation Markers?

The concept evolved from the study of systemic inflammation, with the recognition that the brain, previously thought to be immune-privileged, possesses its own resident immune cells (microglia and astrocytes). The identification of specific molecular signatures allowed for the clinical measurement of this localized inflammatory state. This field is now central to psychoneuroendocrinology and longevity research.

What is the Mechanism of Neuroinflammation Markers?

When the CNS is exposed to chronic stress, infection, or metabolic dysfunction, resident microglia become activated, releasing pro-inflammatory cytokines such as IL-6 and TNF-alpha. These signaling molecules disrupt the blood-brain barrier and interfere with neurotransmitter and neuropeptide signaling, including those controlling pituitary hormone release. Monitoring these markers provides a direct window into the brain's inflammatory status and its impact on systemic hormonal health.

Neuroinflammation Markers

Meaning

Neuroinflammation Markers are specific biochemical or cellular indicators, measurable in biological fluids or imaging, that signify the presence and activity of an inflammatory response within the central nervous system (CNS). These markers, which include cytokines, chemokines, and activated glial cells, provide clinical evidence of chronic, low-grade brain inflammation. Elevated levels are often associated with neurodegenerative processes and can profoundly disrupt the hypothalamic-pituitary axes, impairing hormonal regulation.