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Neuroinflammation Lipid Mediators

Meaning

Neuroinflammation lipid mediators are bioactive lipid molecules derived from the enzymatic breakdown of membrane phospholipids that act as signaling molecules to initiate, propagate, or resolve the inflammatory response within the central nervous system. This class includes pro-inflammatory eicosanoids, such as prostaglandins and leukotrienes, and anti-inflammatory, pro-resolving mediators (SPMs), like resolvins and protectins. The balance between these opposing lipid signals dictates the trajectory of neuroinflammation and its impact on neuronal survival.