What is the Origin of Neurohormonal Signaling Pathways?

This term is a core concept in neuroendocrinology, a field that formally emerged in the mid-20th century with the discovery of hypothalamic releasing and inhibiting hormones. The term is a compound of 'neuro,' referring to the nervous system, and 'hormonal,' referring to the endocrine system, precisely defining the combined nature of this communication. It describes the critical interface between the brain and the body's systemic regulation.

What is the Mechanism of Neurohormonal Signaling Pathways?

A classic example is the hypothalamic-pituitary-gonadal (HPG) axis, where neurons in the hypothalamus release Gonadotropin-releasing hormone (GnRH), which acts on the pituitary. The pituitary then releases gonadotropins into the circulation, which travel to the gonads to regulate sex steroid production. This mechanism ensures that external stimuli, processed by the nervous system, result in precise, widespread, and sustained hormonal adjustments throughout the body.

Neurohormonal Signaling Pathways ∞ Area

Neurohormonal Signaling Pathways

Meaning

Neurohormonal Signaling Pathways are the complex, interconnected routes by which the nervous system and the endocrine system communicate and coordinate physiological functions across the body. These pathways involve the release of hormones from specialized neurosecretory cells, which then travel through the bloodstream to act on distant target cells. They represent the body’s master control system, integrating sensory input with systemic metabolic and homeostatic responses.