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Neurohormonal Blockade

Meaning

Neurohormonal Blockade is a therapeutic strategy involving the pharmacological interruption of signaling pathways mediated by the interplay of the nervous system and the endocrine system. This intervention is primarily utilized in clinical cardiology and endocrinology to mitigate the detrimental, long-term effects of chronically overactive systems, such such as the sympathetic nervous system and the renin-angiotensin-aldosterone system (RAAS). The goal is to reduce systemic stress and protect target organs from sustained pathological signaling. This blockade helps restore a healthy homeostatic balance.