What is the Origin of Neurogenic Compounds?

This term is derived from the Greek neuron (nerve) and -genesis (creation or beginning), defining substances that promote the formation of new neural tissue and connections. The concept gained clinical traction with the discovery of adult neurogenesis in the hippocampus and the subsequent global search for therapeutic modulators to harness this process.

What is the Mechanism of Neurogenic Compounds?

These compounds primarily function by increasing the expression and activity of critical neurotrophic factors, most notably Brain-Derived Neurotrophic Factor (BDNF). BDNF acts on TrkB receptors to promote robust neuronal survival and synaptic plasticity. Certain hormones and peptides can be considered neurogenic, as they directly or indirectly enhance the proliferation and differentiation of neural stem cells in specific, functional brain regions.

Neurogenic Compounds ∞ Area

Neurogenic Compounds

Meaning

Neurogenic Compounds are a category of pharmacological or nutritional agents that possess the biological capability to stimulate neurogenesis, which is the growth and development of new neurons and glia in the brain. These compounds are of significant clinical interest for their potential to enhance cognitive function, mood, and accelerate recovery following neurological injury or age-related decline. They actively support the structural plasticity and functional reserve of the central nervous system.