What is the Origin of Neurogenesis Upregulation?

This concept emerged from the paradigm shift in neuroscience that proved neurogenesis, the creation of new neurons, continues into adulthood, challenging older dogmas of a fixed brain structure. 'Upregulation' is the clinical goal, seeking to maximize this regenerative process for improved brain health and functional capacity. The discovery of the impact of exercise on neurogenesis validated this therapeutic target.

What is the Mechanism of Neurogenesis Upregulation?

Upregulation is achieved by stimulating the molecular pathways that control neural stem cell differentiation and survival, often involving the strategic use of exercise, dietary factors, and specific hormonal signals. Neurotrophic factors, most notably BDNF, are critical mediators of this process, promoting the maturation and integration of new neurons into existing hippocampal circuits. A robust rate of neurogenesis supports cognitive flexibility, emotional resilience, and the capacity for new learning.

Neurogenesis Upregulation

Meaning

Neurogenesis Upregulation is the clinical and physiological strategy of increasing the rate of proliferation and survival of new neurons from neural stem cells within the adult brain, primarily occurring in the subgranular zone of the hippocampus. This process is essential for specific forms of learning, memory, and mood regulation. Maximizing neurogenesis is a key objective for promoting brain plasticity and resilience against neurological decline.