What is the Origin of Neurogenesis Timelines?

This concept stems from the discovery of adult neurogenesis, a paradigm shift in neuroscience, and emphasizes the time-dependent nature of this complex cellular process. "Timelines" highlights the developmental sequence from neural stem cell proliferation to mature neuron functional integration.

What is the Mechanism of Neurogenesis Timelines?

The process is governed by a precise sequence of molecular events, including the proliferation of neural stem cells, their migration, differentiation into mature neurons, and finally, their functional integration into the neural network. Glucocorticoids, like cortisol, can suppress neurogenesis, while hormones such as DHEA, estrogen, and growth hormone can promote it by increasing neurotrophic factor expression, thereby accelerating the timeline for new cell incorporation.

Neurogenesis Timelines ∞ Area

Neurogenesis Timelines

Meaning

Neurogenesis Timelines refer to the chronological and spatial patterns of new neuron generation and integration into existing neural circuits, primarily occurring in the subgranular zone of the hippocampus and the subventricular zone. These timelines are highly variable across the lifespan and are sensitive to hormonal, environmental, and behavioral influences. Understanding these timelines is crucial for developing interventions to enhance cognitive function and emotional resilience.