What is the Origin of Neurogenesis Timeline?

This term is a construct within neurobiology and regenerative medicine, providing a chronological framework for the process of neurogenesis—the birth of new neurons. In endocrinology, it highlights the profound influence of hormones on brain plasticity and long-term cognitive health. Research in this area is fundamental to understanding age-related cognitive decline.

What is the Mechanism of Neurogenesis Timeline?

The timeline is critically regulated by circulating hormones, particularly estrogen, testosterone, and growth factors like IGF-1 and BDNF, which promote stem cell proliferation and survival. The mechanism involves these factors activating specific signaling cascades that upregulate transcription factors essential for neuronal differentiation. A continuous, functional neurogenesis timeline is supported by a robust, balanced hormonal milieu.

Neurogenesis Timeline

Meaning

The temporal course of generating new functional neurons from neural stem cells, primarily occurring in specific regions of the adult brain like the hippocampus. This timeline tracks the proliferation, migration, and differentiation of these new cells, which is highly sensitive to hormonal regulation. A healthy neurogenesis timeline is essential for maintaining cognitive flexibility and mood regulation throughout life.