The array of biological conditions and targeted external stimuli that promote the proliferation, differentiation, and survival of new functional neurons, primarily within the adult mammalian hippocampus. This process is vital for learning, memory consolidation, and cognitive reserve maintenance. We seek to cultivate an environment conducive to the birth of new neural cells. This plasticity is not limited to development.
Origin
This concept moves from classical developmental neuroscience into the study of adult brain plasticity, driven by discoveries showing that neurogenesis persists throughout life in specific regions. The systems approach recognizes that multiple factors must align for successful neuronal integration. It reflects an understanding of dynamic brain remodeling.
Mechanism
Support systems function by upregulating critical growth factors, most notably Brain-Derived Neurotrophic Factor (BDNF), which acts via its TrkB receptor to ensure neuronal survival and differentiation. Furthermore, maintaining a favorable endocrine profile, such as balanced thyroid hormone levels and reduced systemic inflammation, creates the necessary permissive environment for hippocampal progenitor cells to mature and integrate into existing circuitry.
We use cookies to personalize content and marketing, and to analyze our traffic. This helps us maintain the quality of our free resources. manage your preferences below.
Detailed Cookie Preferences
This helps support our free resources through personalized marketing efforts and promotions.
Analytics cookies help us understand how visitors interact with our website, improving user experience and website performance.
Personalization cookies enable us to customize the content and features of our site based on your interactions, offering a more tailored experience.