Neurogenesis Support Strategies are clinical and lifestyle interventions specifically designed to promote the proliferation and survival of new neurons, primarily within the hippocampus, a brain region critical for memory and emotional regulation. This is a fundamental approach to enhancing neuroplasticity and combating age-related cognitive decline by increasing the functional reserve of the brain. These strategies often involve a combination of specific nutritional factors, targeted physical activity, and environmental enrichment, all proven to stimulate the production of neurotrophic factors. The ultimate goal is to facilitate the integration of these newly formed neurons into existing neural circuits, thereby improving cognitive and affective function.
Origin
The term is rooted in developmental and adult neuroscience, following the paradigm-shifting discovery that neurogenesis, the birth of new neurons, continues throughout adulthood. “Support Strategies” emphasizes the applied, actionable steps derived from this biological knowledge. This field has transitioned from a purely theoretical concept to a critical area of clinical intervention in longevity medicine.
Mechanism
The mechanism is heavily dependent on the regulation of key growth factors, particularly Brain-Derived Neurotrophic Factor (BDNF) and Vascular Endothelial Growth Factor (VEGF). Specific types of physical exercise, notably aerobic activity, are potent inducers of BDNF expression, which acts on neural stem cells in the subgranular zone of the hippocampus to promote their division and differentiation into mature neurons. Furthermore, certain dietary components and nutraceuticals can modulate signaling pathways, such as the CREB pathway, to enhance the survival and successful integration of these new neurons into the existing hippocampal circuitry.
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