Neurogenesis Support Compounds are a class of therapeutic agents, including specific nutraceuticals and small peptides, designed to promote the creation of new neurons in the adult brain, primarily within the hippocampus. The clinical objective is to enhance cognitive function, improve memory consolidation, and bolster emotional resilience by actively stimulating this intrinsic regenerative process. These compounds are a key focus in advanced brain health and longevity protocols.
Origin
The term emerged following the scientific paradigm shift that definitively confirmed neurogenesis, the birth of new brain cells, continues throughout life, primarily driven by factors like Brain-Derived Neurotrophic Factor (BDNF). Support compounds are the clinical translation of this discovery, aiming to harness this natural neural plasticity for therapeutic gain.
Mechanism
These compounds function by either directly mimicking or indirectly stimulating the action of endogenous neurotrophic factors, such as BDNF and NGF, which bind to neuronal receptors and initiate critical signaling cascades. This stimulation promotes the proliferation and differentiation of neural stem cells and supports the survival and functional integration of new neurons into existing neural circuits. The net result is an increase in brain plasticity and functional cognitive reserve.
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