A class of dietary supplements and nutraceuticals specifically formulated with compounds believed to stimulate or support the process of neurogenesis, the creation of new neurons in the adult brain, primarily within the hippocampus. These agents are utilized to potentially enhance cognitive reserve, improve learning capacity, and support mood regulation. They represent a novel strategy for brain longevity.
Origin
The concept of stimulating new neuron growth in adults is relatively recent, fundamentally challenging the older scientific dogma that the adult brain was fixed and incapable of producing new cells. The development of these supplements follows the discovery of adult neurogenesis and the identification of natural compounds that influence this critical process.
Mechanism
These supplements typically work by increasing the expression of neurotrophic factors, most notably Brain-Derived Neurotrophic Factor (BDNF), which is a critical molecule for neuronal survival, differentiation, and synaptogenesis. Ingredients often include specific flavonoids, polyunsaturated fatty acids, and certain amino acid derivatives that cross the blood-brain barrier. These compounds directly influence progenitor cell proliferation and the maturation of new neurons in the dentate gyrus, thereby supporting structural brain health.
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