What is the Origin of Neurogenesis Regulation?

The term is rooted in neuroscience and developmental biology, combining the Greek neuron (nerve) and genesis (creation). While initially believed to cease after early development, the discovery of adult neurogenesis, particularly in the late 20th century, established the basis for its therapeutic "regulation." The clinical application of this term is central to modern regenerative medicine and neuroendocrinology.

What is the Mechanism of Neurogenesis Regulation?

Regulation occurs via a cascade of molecular signals, prominently involving neurotrophic factors like Brain-Derived Neurotrophic Factor (BDNF) and various steroid hormones, including testosterone and estrogen. These factors bind to receptors on progenitor cells, activating intracellular signaling pathways that promote cell division and maturation into functional neurons. Furthermore, physical activity and specific dietary components are known to modulate the hippocampal microenvironment, acting as powerful external regulators of this vital regenerative mechanism.

Neurogenesis Regulation

Meaning

Neurogenesis Regulation is the complex biological process that controls the proliferation, differentiation, and survival of new neurons from neural stem cells and progenitor cells in specific regions of the adult brain, primarily the hippocampus. The clinical focus of regulation is to enhance this process, as diminished neurogenesis is implicated in age-related cognitive decline, mood disorders, and neurodegenerative diseases. This biological process is highly sensitive to hormonal signals and environmental factors. Promoting neurogenesis is a key strategy for cognitive resilience.