What is the Origin of Neurogenesis Rate?

The term combines 'neurogenesis,' the process of new neuron creation, with 'rate,' a mathematical measure of change over time, originating from cellular and molecular neuroscience. Clinical interest in the rate grew as researchers identified its modifiability by lifestyle factors and hormonal status. It is a measurable biomarker for the dynamic health of the adult brain.

What is the Mechanism of Neurogenesis Rate?

The neurogenesis rate is tightly regulated by a complex interplay of systemic and local factors. Systemic factors include the concentration of stress hormones like cortisol, which can suppress the rate, and anabolic hormones like IGF-1 and estrogen, which can stimulate it. Locally, the rate is controlled by the balance of pro- and anti-inflammatory cytokines and the concentration of BDNF within the hippocampal niche. Modulating these factors is the clinical target for enhancing the rate.

Neurogenesis Rate ∞ Area

Neurogenesis Rate

Meaning

The quantitative measure of the speed and volume at which new functional neurons are generated from neural stem cells, primarily in the hippocampal subgranular zone, over a defined period. This rate is a direct physiological index of brain plasticity, cognitive reserve, and the capacity for mood regulation. A clinically optimized neurogenesis rate is considered vital for preventing age-related cognitive decline and enhancing mental well-being.