What is the Origin of Neurogenesis Potential?

Combining "neurogenesis" (the birth of new neurons) and "potential" (the capacity for development), this term highlights the lifelong, albeit regulated, ability for structural neural remodeling. This capacity is significantly influenced by the systemic hormonal environment and local trophic factor availability. It moves beyond static views of brain structure.

What is the Mechanism of Neurogenesis Potential?

The process involves the proliferation and differentiation of neural stem cells, which is highly sensitive to environmental cues. Growth factors such as BDNF, often upregulated by physical activity and balanced steroid hormone signaling, act as powerful promoters of this differentiation cascade. Conversely, chronic elevation of catabolic hormones like glucocorticoids can suppress the proliferation phase, effectively limiting this regenerative potential.

Neurogenesis Potential ∞ Area

Neurogenesis Potential

Meaning

Neurogenesis Potential refers to the inherent capacity of the adult brain, primarily within the subgranular zone of the dentate gyrus, to generate new functional neurons capable of integrating into existing neural circuits. Maximizing this potential is a key objective in promoting cognitive resilience against neurodegenerative processes. It reflects the brain’s plasticity reserve.