What is the Origin of Neurogenesis Modulation?

This concept stems from the discovery of adult neurogenesis, challenging the long-held dogma that the adult mammalian brain could not generate new neurons. The term "Modulation" signifies the use of therapeutic or lifestyle interventions to influence this naturally occurring biological process. This field bridges neuroscience, psychiatry, and regenerative medicine.

What is the Mechanism of Neurogenesis Modulation?

Modulation is achieved by influencing the molecular environment of neural stem cells through factors such as exercise, caloric restriction, specific pharmacological agents, and the optimization of neurotrophic factors like BDNF. Hormones, particularly glucocorticoids and sex steroids, play a critical regulatory role, with balanced levels promoting neurogenesis and chronic stress inhibiting it. The mechanism essentially involves creating an internal milieu conducive to the growth and integration of new functional neurons.

Neurogenesis Modulation

Meaning

The process of intentionally altering the rate of proliferation, migration, and survival of new neurons within the adult brain, primarily occurring in the subgranular zone of the hippocampus. This modulation is a key target for improving cognitive function, memory formation, and emotional resilience, as impaired neurogenesis is implicated in various neurodegenerative and mood disorders. The goal is to sustain a healthy rate of neuronal turnover.