What is the Origin of Neurogenesis Mechanisms?

The term is derived from neurobiology, where 'neuro' means nerve and 'genesis' means creation or beginning. The modern clinical focus on these mechanisms stems from the discovery that neurogenesis persists in the adult mammalian brain, challenging earlier dogma.

What is the Mechanism of Neurogenesis Mechanisms?

The process is tightly regulated by a host of signaling molecules, including neurotrophic factors like Brain-Derived Neurotrophic Factor (BDNF) and Vascular Endothelial Growth Factor (VEGF). Endocrine factors, such as estrogen, progesterone, and testosterone, have been shown to directly stimulate progenitor cell division and survival. Lifestyle factors, including physical exercise and calorie restriction, are known to up-regulate these mechanisms, offering non-pharmacological avenues for promoting neuronal regeneration and plasticity.

Neurogenesis Mechanisms

Meaning

Neurogenesis mechanisms refer to the complex cellular and molecular pathways responsible for the proliferation, migration, and differentiation of new neurons from neural stem cells and progenitor cells. In the adult brain, this process primarily occurs in the subgranular zone of the hippocampus and the subventricular zone. Enhancing these mechanisms is a key therapeutic goal for improving cognitive function, particularly learning and memory, and for promoting structural resilience against neurodegeneration.