What is the Origin of Neurogenesis Enhancement?

The term combines "neurogenesis," derived from the Greek 'neuron' (nerve) and 'genesis' (creation), with "enhancement," signifying an increase or improvement in the rate or extent of the process beyond the basal level. It is a key concept within neurobiology and regenerative medicine that has gained significant attention since the definitive confirmation of adult neurogenesis. The field explores the therapeutic potential of leveraging the brain's intrinsic, albeit limited, regenerative capacity.

What is the Mechanism of Neurogenesis Enhancement?

Enhancement is mediated by various physiological and pharmacological factors that positively influence the neural stem cell niche environment. Key mechanisms involve the upregulation of essential neurotrophic factors, such as Brain-Derived Neurotrophic Factor (BDNF), and the beneficial modulation of specific neurotransmitter systems, including the serotonergic and GABAergic pathways. Physical exercise, caloric restriction, and certain hormonal interventions, particularly those involving appropriate levels of sex steroids and growth factors, have been shown to influence the signaling pathways that promote the survival and successful integration of newly formed neurons.

Neurogenesis Enhancement

Meaning

Neurogenesis enhancement is the deliberate promotion of the proliferation, differentiation, and survival of new functional neurons from neural stem cells and progenitor cells within the adult brain, primarily localized to the hippocampus. This biological process is a crucial component of brain plasticity, essential for the formation of new memories, complex learning, and the maintenance of emotional and mood regulation. Clinical and lifestyle strategies aimed at this enhancement are focused on improving cognitive function and increasing resilience against neurodegenerative and mood disorders.