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Neurofibrillary Tangle Mitigation

Meaning

Neurofibrillary Tangle Mitigation refers to the clinical and biological strategies focused on reducing the formation, accumulation, or pathological effects of neurofibrillary tangles (NFTs) within neuronal cell bodies. These tangles are abnormal aggregates of hyperphosphorylated tau protein, a hallmark pathology of Alzheimer’s disease and other tauopathies, leading to cytoskeletal collapse and subsequent neuronal death. Effective mitigation is a crucial objective in longevity science, aiming to preserve the structural integrity and functional connectivity of the neural networks responsible for memory and hormonal control.