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Neuroendocrinological Aging

Meaning

Neuroendocrinological Aging describes the progressive, inevitable decline in the functional integrity and coordinated communication between the nervous system and the endocrine system that occurs over the human lifespan. This process is characterized by alterations in the pulsatile release of hypothalamic-pituitary hormones, reduced peripheral gland responsiveness, and decreased sensitivity of target tissues to circulating hormones. The consequence is a cascade of systemic dysregulation, impacting sleep, metabolism, stress response, and reproductive function, significantly contributing to the overall aging phenotype.