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Neuroendocrine Threshold

Meaning

The Neuroendocrine Threshold represents the minimum necessary intensity of a neural or humoral stimulus required to elicit a measurable and definitive hormonal response from the neuroendocrine system. This physiological sensitivity level determines the magnitude of the body’s reaction to internal changes, such as stress or shifts in blood osmolarity. A lower threshold indicates hypersensitivity, meaning a small stimulus will trigger a large hormonal release, while a high threshold suggests blunted responsiveness. Clinically, an altered threshold can be a key indicator of chronic stress adaptation or early-stage endocrine dysfunction.