What is the Origin of Neuroendocrine Theory Aging?

This theory was developed in the mid-20th century, notably by Vladimir Dilman and others, based on observations that age-related diseases often correlate with changes in the secretion patterns of key hormones like growth hormone, thyroid hormones, and sex steroids. It provides a conceptual framework for understanding aging as a failure of communication and control within the body's master regulatory systems. The term remains a central concept in gerontology and anti-aging research.

What is the Mechanism of Neuroendocrine Theory Aging?

The mechanism involves age-related changes in hypothalamic function, leading to reduced sensitivity to negative feedback and altered pulsatile release of releasing hormones. This dysfunction causes a subsequent decline in the output of peripheral endocrine glands, such as the adrenals and gonads. The resulting hormonal imbalance, or 'hormonal cascade hypothesis,' directly impairs metabolic rate, immune function, and cellular repair processes, thereby accelerating systemic aging.

Neuroendocrine Theory Aging

Meaning

A prominent theory of aging that posits the primary driver of senescence is the progressive dysfunction and decline of the neuroendocrine system, specifically the hypothalamic-pituitary axis. This decline leads to dysregulated hormonal signaling, a loss of homeostatic control, and a cascade of downstream effects that accelerate age-related physiological deterioration. The theory emphasizes the central role of the brain and endocrine glands in governing the aging process.