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Neuroendocrine System Precision

Meaning

The optimal, tightly controlled, and accurate coordination of signaling between the nervous system and the endocrine system, ensuring homeostatic balance and appropriate physiological responses to internal and external stimuli. This precision involves the pulsatile, rhythmic, and dose-dependent secretion of hormones and neurotransmitters, alongside the appropriate sensitivity and response of target tissues. Loss of neuroendocrine precision is a hallmark of aging and chronic stress, manifesting as dysregulated hormonal rhythms and impaired feedback loops.