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Neuroendocrine System Plasticity

Meaning

Neuroendocrine System Plasticity describes the inherent capacity of the interconnected nervous and endocrine systems to adapt, reorganize, and modify their structure and function in response to sustained changes in internal or external environments, such as chronic stress, dietary shifts, or aging. This adaptive flexibility allows the body to maintain homeostasis across various life stages and environmental challenges, but it also means that chronic, negative inputs can lead to persistent, maladaptive changes in hormonal set points. Clinical efforts often focus on leveraging this plasticity for therapeutic benefit.