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Neuroendocrine System Interference

Meaning

Any external or internal factor that disrupts the intricate, reciprocal communication network between the nervous system and the endocrine system, primarily involving the hypothalamus, pituitary gland, and peripheral endocrine organs. Common interferences include chronic stress, environmental toxins, inflammatory cytokines, or certain pharmacological agents that can desynchronize hormonal pulses and alter receptor sensitivity. Such interference leads to systemic dysregulation, manifesting as mood disturbances, sleep disorders, and metabolic or reproductive dysfunction.