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Neuroendocrine Substrate Availability

Meaning

Neuroendocrine Substrate Availability describes the systemic concentration and delivery of essential biochemical precursors and cofactors required for the synthesis and release of hormones and neurotransmitters by the central nervous system and endocrine glands. This includes amino acids for catecholamines and peptides, cholesterol for steroid hormones, and crucial minerals and vitamins that act as enzymatic cofactors. Optimal availability is a prerequisite for maintaining the functional integrity of the entire neuroendocrine network.