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Neuroendocrine Signaling Interference

Meaning

Neuroendocrine Signaling Interference describes the detrimental disruption of the intricate communication pathways between the nervous system and the endocrine system, resulting in dysregulated hormone release, synthesis, or action. This interference can occur at any critical juncture along the major hormonal axes, such as the HPA or HPG axis, and is frequently mediated by chronic inflammation, environmental endocrine-disrupting chemicals, or persistent psychological stress. The consequence is a profound loss of precision in the body’s hormonal feedback loops, ultimately leading to systemic imbalance and functional decline.