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Neuroendocrine Senescence Reversal

Meaning

Neuroendocrine Senescence Reversal is the therapeutic goal of restoring youthful function to the interconnected nervous and endocrine systems, specifically targeting the age-related decline in the Hypothalamic-Pituitary-Adrenal (HPA) and Hypothalamic-Pituitary-Gonadal (HPG) axes. Senescence, or biological aging, leads to blunted hormonal rhythms and reduced receptor sensitivity, which contributes significantly to systemic decline. Reversal involves re-establishing robust, rhythmic, and responsive hormonal signaling. This strategy aims to reset the body’s master control systems.