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Neuroendocrine Recalibration

Meaning

Neuroendocrine recalibration is a therapeutic concept that describes the process of systematically adjusting and restoring the optimal set points and regulatory sensitivity of the interconnected nervous and endocrine systems. This intricate system, often centered on the Hypothalamic-Pituitary-Adrenal (HPA) and Hypothalamic-Pituitary-Gonadal (HPG) axes, becomes dysregulated by chronic stress, aging, or pathology, leading to hormonal imbalances. The goal of recalibration is to improve the communication and feedback loops between the brain and the hormone-producing glands, thereby promoting a more resilient and adaptive physiological state. Achieving this requires a holistic, integrated clinical strategy encompassing lifestyle modification, nutritional support, and, where necessary, targeted hormone or precursor therapy.