What is the Origin of Neuroendocrine Neoplasms?

The term is a combination of "neuroendocrine," describing the dual nature of the cell of origin, and "neoplasm," the medical term for an abnormal mass of tissue, or a tumor. The historical recognition of their unique cellular features led to this specific classification.

What is the Mechanism of Neuroendocrine Neoplasms?

NENs originate from the diffuse neuroendocrine system, which is composed of specialized cells that are widely distributed throughout the body. The neoplastic transformation often involves genetic mutations that lead to uncontrolled cell growth and, critically, dysregulated synthesis and secretion of bioactive peptides and hormones. The clinical syndrome experienced by the patient, such as flushing or diarrhea, is a direct result of the overproduction of these specific hormones, such as serotonin or insulin.

Neuroendocrine Neoplasms ∞ Area

Neuroendocrine Neoplasms

Meaning

Neuroendocrine Neoplasms (NENs) are a diverse group of tumors arising from cells that possess characteristics of both nerve cells and hormone-producing endocrine cells. These tumors can occur throughout the body, most commonly in the gastrointestinal tract, pancreas, and lungs, and often secrete excessive amounts of hormones, leading to specific clinical syndromes. The spectrum of NENs ranges from indolent, slow-growing tumors to aggressive, high-grade carcinomas.