What is the Origin of Neuroendocrine Immune Modulation?

This field arose from psychoneuroimmunology, expanding to incorporate the detailed actions of hormones as mediators between brain states and immune cell function. It recognizes that stress responses inherently involve hormonal and immune components working in concert.

What is the Mechanism of Neuroendocrine Immune Modulation?

Hormones released under stress, such as cortisol, act through glucocorticoid receptors on immune cells to dampen inflammatory responses, preventing excessive immune activation. Conversely, pro-inflammatory cytokines produced by immune cells can signal back to the hypothalamus, altering the secretion patterns of CRH and subsequently affecting the entire endocrine axis. This constant cross-regulation maintains homeostasis.

Neuroendocrine Immune Modulation ∞ Area

Neuroendocrine Immune Modulation

Meaning

Neuroendocrine Immune Modulation describes the intricate bidirectional communication network linking the nervous system, the endocrine system, and the immune defenses of the body. This integrated control system ensures that physiological responses to internal and external challenges are coordinated effectively. It is the basis of systemic adaptation and resilience.