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Neuroendocrine-Immune Interface

Meaning

The Neuroendocrine-Immune Interface is a highly integrated, bidirectional communication network comprising the nervous, endocrine, and immune systems, which collectively regulate the body’s physiological response to internal and external stressors. This complex interface utilizes signaling molecules—such as hormones, neurotransmitters, and cytokines—to maintain allostasis and orchestrate adaptive responses. Clinically, a disruption at this interface, often due to chronic stress or inflammation, is central to the pathophysiology of numerous conditions, including autoimmune disorders and stress-induced hormonal dysregulation.