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Neuroendocrine Fatigue Syndrome

Meaning

Neuroendocrine Fatigue Syndrome describes a complex clinical state characterized by profound, persistent, and often debilitating exhaustion that is directly attributable to chronic dysregulation within the interconnected nervous and endocrine systems. This syndrome involves the maladaptation of the Hypothalamic-Pituitary-Adrenal (HPA) axis and altered neurotransmitter balance, resulting in impaired energy regulation and a diminished capacity to cope with stress. It is a functional diagnosis that highlights systemic communication failure.