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Neuroendocrine Damage

Meaning

Neuroendocrine damage describes the pathological impairment of the intricate signaling and feedback loops that connect the central nervous system and the peripheral endocrine system, primarily affecting the hypothalamic-pituitary axes. This damage often results from chronic, overwhelming psychological stress, physical trauma, or prolonged inflammatory states, leading to a sustained, pathological disruption in the secretion and regulation of key hormones like cortisol, thyroid hormones, and sex steroids. Clinically, it often presents as a central form of hormonal insufficiency or chronic dysregulation.