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Neuroendocrine Crosstalk Dysregulation

Meaning

Neuroendocrine Crosstalk Dysregulation refers to a pathological disturbance in the intricate bidirectional communication network that links the nervous system and the endocrine system, particularly involving the Hypothalamic-Pituitary-Adrenal (HPA) and Hypothalamic-Pituitary-Gonadal (HPG) axes. This dysregulation means that neural signals from the brain, often related to stress or circadian rhythm, are improperly translated into hormonal outputs, or vice-versa. It is a fundamental cause of chronic stress-related disorders, reproductive issues, and persistent mood disturbances.