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Neuroendocrine Communication Integrity

Meaning

Neuroendocrine communication integrity refers to the robust, coordinated, and efficient signaling capacity between the nervous system and the endocrine system, a fundamental requirement for maintaining physiological homeostasis. This integrity ensures that the hypothalamic-pituitary-adrenal (HPA) axis, the hypothalamic-pituitary-gonadal (HPG) axis, and other regulatory loops can accurately interpret neural input and translate it into appropriate hormonal output. When communication integrity is compromised, chronic stress, sleep disruption, or mood disorders can manifest due to dysregulated cortisol, melatonin, or sex hormone rhythms. Maintaining this functional coherence is paramount for optimal mental and physical health.