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Neuroendocrine Axis Signaling

Meaning

Neuroendocrine Axis Signaling describes the complex, bidirectional communication pathways that integrate the nervous system and the endocrine system, ensuring a coordinated physiological response to internal and external stimuli. This signaling involves the hypothalamus and pituitary gland acting as the central interface, translating neural inputs into hormonal outputs that regulate critical functions like stress response, metabolism, reproduction, and mood. Dysregulation in this axis, such as chronic HPA axis overactivation, is a central driver of many chronic hormonal health issues. The integrity of this communication is paramount for systemic homeostasis.