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Neuroendocrine Axes Integrity

Meaning

Neuroendocrine axes integrity refers to the robust, uncompromised functional state of the interconnected signaling pathways between the nervous system and the endocrine system. This integrity is essential for maintaining systemic homeostasis, as these axes—such as the HPA, HPT, and HPG—regulate stress response, metabolism, and reproduction. A high degree of integrity signifies resilient, accurate communication and feedback loops, allowing the body to adapt efficiently to both internal and external challenges. Compromised integrity is often an early indicator of biological aging or chronic stress.