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Neuroendocrine Attenuation

Meaning

Neuroendocrine Attenuation describes the process of physiologically reducing or dampening an excessive or chronic output from the neuroendocrine axes, particularly the Hypothalamic-Pituitary-Adrenal (HPA) axis. This controlled reduction is a critical therapeutic goal in managing conditions driven by chronic stress, where sustained high levels of cortisol or catecholamines lead to allostatic overload and systemic dysfunction. Successful attenuation aims to restore the natural, rhythmic, and balanced responsiveness of these control systems.