What is the Origin of Neuroendocrine Aging Theory?

This theory is a foundational concept in gerontology and endocrinology, linking the nervous system (neuro) and the endocrine system (endocrine) to the process of aging. Early research focused on the decline of growth hormone and DHEA, suggesting a central regulatory clock. It has evolved to encompass the interconnectedness of the HPA, HPG, and HPT axes as key modulators of the aging trajectory.

What is the Mechanism of Neuroendocrine Aging Theory?

The proposed mechanism involves a decrease in the pulsatile release of hypothalamic-releasing hormones, such as Growth Hormone-Releasing Hormone (GHRH) and Gonadotropin-Releasing Hormone (GnRH). This blunted pulsatility leads to reduced pituitary stimulation and subsequent lower circulating levels of key anabolic and metabolic hormones. The resulting hormonal deficiency then contributes to sarcopenia, immunosenescence, and metabolic dysfunction in target organs, driving the overall aging phenotype.

Neuroendocrine Aging Theory ∞ Area

Neuroendocrine Aging Theory

Meaning

The Neuroendocrine Aging Theory posits that the primary driver of systemic aging originates from the progressive dysfunction and dysregulation of the neuroendocrine system. This theory suggests that age-related decline in hormonal rhythmicity and signaling, particularly within the Hypothalamic-Pituitary axes, leads to downstream pathologies in peripheral tissues. The hypothalamic control centers become less sensitive to feedback, resulting in an overall decline in homeostatic control and resilience. This theoretical framework provides a rationale for hormonal optimization as a strategy to mitigate age-related decline.