Neurodegenerative Senescence Delay is the therapeutic objective of slowing the accumulation of age-related cellular damage and functional decline specifically within the central nervous system, thereby postponing the onset or progression of neurodegenerative diseases. This clinical strategy focuses on mitigating neuronal senescence, improving synaptic plasticity, and enhancing neurotrophic factor support to maintain cognitive vitality. It represents a critical area of longevity medicine aimed at preserving brain health across the lifespan.
Origin
The term is a synthesis of “neurodegenerative,” referring to the decline of neuronal structure and function, and “senescence,” the process of cellular aging and irreversible growth arrest. The clinical goal of “Delay” emphasizes a proactive, preventative approach rooted in the understanding that neuronal aging is a plastic process that can be therapeutically modulated.
Mechanism
Delay is achieved by intervening in molecular pathways that contribute to neuronal aging, such as reducing oxidative stress, clearing misfolded proteins (autophagy), and enhancing mitochondrial biogenesis within neurons. Hormonal modulation plays a role, as neurotrophic steroids can increase the expression of brain-derived neurotrophic factor (BDNF), promoting synaptic health and neuronal survival. These interventions collectively work to maintain the structural and functional integrity of the neural network, extending its functional lifespan.
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