The clinical application of preventative and therapeutic strategies aimed at reducing an individual’s specific, quantifiable risk of developing age-related neurodegenerative conditions like Alzheimer’s or Parkinson’s disease. This involves targeted interventions that address known hormonal, metabolic, and inflammatory risk factors. It represents a proactive stance in cognitive longevity.
Origin
This concept stems from the convergence of neurology, gerontology, and risk assessment models in clinical practice. ‘Modulation’ signifies the active adjustment of biological pathways to decrease probability.
Mechanism
Modulation often focuses on optimizing the neuroendocrine environment, ensuring adequate levels of neuroprotective hormones like testosterone, estrogen, and thyroid hormones, which support neuronal health and synaptic function. It also involves reducing systemic inflammation and improving cerebral blood flow. Furthermore, specific compounds may be used to clear pathological protein aggregates or enhance neurogenesis in critical brain regions.
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