A proactive, clinical strategy focused on reducing the probability and slowing the onset of age-related neurological disorders, including Alzheimer’s and Parkinson’s disease. Mitigation involves identifying and managing modifiable risk factors through targeted nutritional, lifestyle, and hormonal interventions. This approach prioritizes preserving neuronal health and cognitive reserve throughout the lifespan. It represents a shift from treatment to prevention in the domain of brain health.
Origin
This concept arises from the epidemiological and molecular study of neurodegenerative diseases, where the focus has moved toward identifying pre-clinical risk markers. Mitigation, from the Latin mitigare (to soften or alleviate), emphasizes the reduction of disease impact.
Mechanism
Key mechanisms include reducing chronic neuroinflammation by balancing the activity of microglial cells and suppressing pro-inflammatory cytokine release. Maintaining mitochondrial integrity in neurons prevents oxidative stress, a major contributor to protein aggregation. Hormonal balance, especially the maintenance of neurosteroids like pregnenolone and DHEA, is crucial for supporting synaptic function and myelin sheath integrity, which collectively reduces vulnerability to degeneration.
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