This is a specialized, evidence-based nutritional intervention designed to reduce the risk or slow the progression of neurodegenerative conditions, such as Alzheimer’s and Parkinson’s disease, by targeting shared pathological mechanisms. The diet emphasizes specific macronutrient ratios, high levels of neuroprotective micronutrients, and a low inflammatory load to support neuronal integrity. It is a core component of a holistic approach to cognitive longevity.
Origin
The concept emerged from epidemiological and clinical studies that identified the strong link between dietary patterns and brain health outcomes, particularly the Mediterranean and MIND diets. The term combines the clinical focus of “neurodegenerative disease” with the therapeutic tool of “diet.” This field is rapidly advancing as the connection between metabolic dysfunction, gut health, and central nervous system pathology becomes clearer.
Mechanism
The diet operates by targeting key mechanisms of neurodegeneration, including chronic neuroinflammation, oxidative stress, and mitochondrial dysfunction in the brain. Specific nutrients, such as omega-3 fatty acids and polyphenols, support synaptic plasticity and enhance the clearance of amyloid plaques and other pathological protein aggregates. Furthermore, by promoting gut microbiome diversity, the diet positively influences the gut-brain axis, modulating systemic inflammation and neurotrophic factor production.
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