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Neurodegenerative Decline

Meaning

Neurodegenerative Decline is the progressive and irreversible loss of structure or function of neurons, encompassing the gradual deterioration of the central and peripheral nervous systems, leading to corresponding cognitive and motor impairment. This clinical trajectory is characterized by the accumulation of misfolded proteins, chronic neuroinflammation, and oxidative stress, which collectively compromise synaptic integrity and neuronal survival. Understanding the hormonal and metabolic factors that contribute to this decline is a central focus of longevity medicine.