Interventions designed to objectively improve specific aspects of higher-order brain function, including memory consolidation, processing speed, and attentional focus, often by optimizing the neuroendocrine environment. This enhancement relies on robust cerebral blood flow, optimal mitochondrial function within neurons, and balanced levels of key neuromodulators. We are optimizing the hardware and software of cognitive processing. Clinical success is measured by improvements in standardized neuropsychological testing.
Origin
This term is a modern synthesis from cognitive neuroscience and functional medicine, where performance metrics are used to guide optimization strategies. ‘Enhancement’ suggests moving beyond baseline function toward peak potential through targeted physiological support.
Mechanism
Enhancement often involves ensuring adequate cerebral perfusion and providing substrates for neurotransmitter synthesis, such as specific amino acid precursors. Hormonal support, particularly optimizing thyroid hormone availability for brain metabolism and cortisol for acute focus, plays a regulatory role. Furthermore, promoting synaptic integrity through factors supporting neurotrophic support underpins sustained functional gains.
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