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Neurochemical Thresholds

Meaning

Neurochemical Thresholds refer to the specific concentration levels of neurotransmitters or the requisite level of receptor occupancy needed to trigger a functional change in a postsynaptic neuron or neural circuit. Clinically, understanding these thresholds is essential for predicting an individual’s psychological and physiological response to stress, reward, and pharmacological intervention. These thresholds are not static; they are dynamically modulated by chronic stress, hormonal status, and genetic factors, determining the sensitivity of the nervous system. Optimal hormonal health helps maintain these thresholds within a resilient range.