Clinical strategies focused on ensuring the availability of precursor molecules, cofactors, and metabolic intermediates required for the synthesis and turnover of brain neurotransmitters. Adequate substrate is essential for supporting rapid synaptic communication. This ensures the brain has the necessary building blocks for optimal function.
Origin
This concept originates in nutritional neuroscience, recognizing that neurotransmitter levels are often limited by the availability of their dietary or endogenous precursors. It highlights the dependence of brain chemistry on systemic supply chains.
Mechanism
The process supports the enzymatic pathways responsible for converting amino acids, like tryptophan or tyrosine, into active signaling agents such as serotonin or dopamine. Sufficient availability of vitamins and minerals, acting as cofactors, ensures these conversion reactions proceed efficiently. This substrate support prevents bottlenecks in the synthesis of crucial neuromodulators that govern mood and focus.
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